In the short term, it's easy to replace the now-disloyal followers with more loyal ones, or at the very least, find a skilled spymaster and chancellor, find ways to make them loyal to you, and have them counter plots your angry nobles will be plotting to kill you right off the bat, but as long as your spymaster is sufficiently skilled he can stop these plots dead in their tracks, and if you can identify the conspirators you can simply order them dead. North Korea mode, a popular strategy which circumvents a lot of the restrictions on ruler actions by adopting a reign of tyranny, stripping lands from vassals, forcibly passing laws they'd never agree to, and executing or banishing anyone who objects.
